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COMPLEMENT C3 NEPHRITIC FACTOR
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DeCS
Descriptor
English
:
Complement C3 Nephritic Factor
Descriptor
Spanish
:
Factor Nefrítico del Complemento 3
Descriptor
Portuguese
:
Fator Nefrítico do Complemento 3
Tree Number:
D12.776.124.486.274.920.287
D12.776.124.486.485.114.323.300
D12.776.124.790.651.114.323.300
D12.776.377.715.548.114.323.300
Definition
English
:
An IgG autoantibody against the ALTERNATIVE PATHWAY
C3 CONVERTASE
, found in serum of
patients
with MESANGIOCAPILLARY
GLOMERULONEPHRITIS
. The binding of this autoantibody to C3bBb stabilizes the enzyme thus reduces the actions of C3b inactivators (
COMPLEMENT FACTOR H
;
COMPLEMENT FACTOR I
). This abnormally stabilized enzyme induces a continuous
COMPLEMENT ACTIVATION
and generation of C3b thereby promoting the assembly of MEMBRANE ATTACK COMPLEX and cytolysis.
Pharmacological Action:
Complement Inactivating Agents
Immunologic Factors
History Note
English
:
2006 (1978)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
22147
Unique Identifier:
D003178
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS